Organ weight analysis in toxicological studies is an important endpoint for identifying target organs in test system. In this article, reference ranges for organ weight ratios of outbred mice (ICR CD-1), as well as their absolute values, are determined.
The intranasal drug delivery has been become increasingly interesting not only for the treatment of acute and chronic nasal cavity diseases but mainly for drug delivery to the central nervous system and/or systemic blood over the past decades.
The aim of the work was to study the possibility of reducing the frequence as well as numbers and volume of spontaneous hepatocarcinomas in CBA male-mice using phytoadaptogen complex dry extract preventive administration.
The scientific and industrial focus of biomedical research using pathogenic biological agents requires a serious comprehensive approach to meeting biological safety requirements. Risk assessment is at the heart of biosafety practice.
Prolonged influence of adverse factors of environment on any biological system is accompanied by accumulation of damages in cell’s DNA and change of reparation systems activity that may lead to emergence of fixed mutations, oncogenesis and cell death.