Spontaneous Age-Related Pathology Of The Urinary System In Rats

DOI: 10.29296/2618723X-2018-04-03

K. Zaikin(1), E. Gayday(2), D. Gayday(2), Ya. Gushchin(1), A. Muzhikyan(1), K. Kryshen(2), M. Makarova(1) 1-Scientific-Production Organization «Houm оf Pharmacy» 188663, Leningradskiy region, Vsevolozhskiy district, Kuzmolovskiy, 3, Zavodskaya st., b. 245, Russia; 2-1Institute of pre-clinical studies 188663, Leningradskiy region, Vsevolozhskiy district, Kuzmolovskiy, 3, Zavodskaya st., b. 245, Russia Е-mail: [email protected]

Keywords: page-related changes rats urinary system pathology of the kidneys and bladder

For citation:

Zaikin K., Gayday E., Gayday D., Gushchin Ya., Muzhikyan A., Kryshen’ K., Makarova M. Spontaneous Age-Related Pathology Of The Urinary System In Rats. Laboratory Animals for Science. 2018; 4. https://doi.org/10.29296/2618723X-2018-04-03


Summary. The article is devoted to spontaneous age-related pathologies of the urinary system of rats detected in animals of control group in a long-term carcinogenesis experiment. Interest in this group of pathologies is relevant during long-term experiments since the elderly rodents’ death is often associated with oncological diseases and pathologies of the kidneys. Knowing of pathologies with spontaneous manifestation in laboratory rats is necessary for correct interpretation of experimental results as well as for the differential diagnosis of «spontaneous» and «induced» pathologies. For the classification of pathologies INHAND nomenclature was used. Histological examination of the organs of urinary system (kidney and bladder) was carried out in 200 males and 200 female Wistar rats aged 24 months. Tumor pathology in the article is not considered. Spontaneous age-related pathology of the urinary system in rats is very common - kidney pathology was found in all 200 males studied and in 165 of 200 females studied. Pathological changes considered as manifestations of chronic progressive nephropathy (such as interstitial inflammatory cell infiltration, glomerulosclerosis, basophilia and atrophy of renal tubule epithelium, tubular dilatation, cylinders in the lumen of tubules, focal interstitial sclerosis of the renal cortex) are most common; all 200 males studied and 140 of 200 females studied were identified. Vesicular dystrophy (vacuolization) of renal tubules epithelium is only pathology of urinary system that is more common in females than in males. Vesicular dystrophy has a diverse pathogenesis its clinical and biological significance is ambiguous it can precede necrosis of epithelium, but it can also occur in normal conditions. Pathology of bladder is less common it was detected in 22 males and 1 female. Among the pathological changes were protein plugs in the lumen of bladder and focal inflammatory cell infiltration of bladder. In the experiments described pathologies should be considered as spontaneous associated with age-related changes in the body.


  1. Gushhin Ya.A., Muzhikyan A.A. Vliyanie fiksiruyushhih zhidkostey na mikroskopicheskuyu strukturu organov melkih laboratornyh zhivotnyh. Mezhdunarodnyy vestnik veterinarii. 2014; 3: 88–95.
  2. Muzhikyan A.A., Makarova M.N., Gushhin Ya.A. Osobennosti gistologicheskoy obrabotki organov i tkaney laboratornyh zhivotnyh. Mezhdunarodnyy vestnik veterinarii. 2014;. 2: 103–9.
  3. Brayton C. Famous Rat Pathology (Phenotypes) [E`lektronnyy resurs]. European College of Veterinary Pathologists. 2017. Rezhim dostupa: www.ecvpath.org/download/896/ - 05.10. 2017
  4. Dixon D., Heider K., Elwell. M.R. Incidence of nonneoplastic lesions in historical control male and female Fischer-344 rats from 90-day toxicity studies. Toxicol. Pathol. 1995; 23: 338–48.
  5. Frazier K.S., Seely J.C., Hard G.C. et al. Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System. J. Toxicol Pathol. 2012; 40: 14S–86S.
  6. Hard G.C., Alden C.L., Bruner R.H. et al. Non-proliferative lesions of the kidney and lower urinary tract in rats. In Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington DC. 1999: 1–32.
  7. Johnson R.C., Dovey-Hartman B.J., Syed J. et al. Vacuolation in renal tubular epithelium of Cd-1 mice. An incidental finding. Toxicol. Pathol. 1998; 26: 789–92.
  8. McInnes E. F. Wistar and Sprague–Dawley rats. In Background Lesions in Laboratory Animals, A Color Atlas (E. F. McInnes, ed.). Elsevier Ltd. 2012; 17–36.
  9. Montgomery C. A. Kidney / C. A. Montgomery, J. C. Seely. In Pathology of the Fischer rat (G. A. Boorman, S. L. Eustis, M. R. Elwell, et al., eds.). Academic Press, San Diego. 1990: 127–52.
  10. Percy D. H. Rat / D. H. Percy, S. W. Barthold. In Pathology of laboratory rodents and rabbits, third ed. (D.H. Percy, S.W. Barthold, eds.). Blackwell Publishing Professional, Iowa, USA. 2007: 125–77.
  11. Saladino B. H. Diseases of Rats. Pathology of Laboratory Animals [E`lektronnyy resurs]. August 2013. Charles Louis Davis and Samuel Wesley Thompson DVM Foundation For the Advancement of Veterinary and Comparative Pathology. Rezhim dostupa: http://www.cldavis.org/cgi-bin/download.cgi?pid=1059 - 05.10.2017
  12. Seely J.C., Hard G.C. Chronic Progressive Nephropathy (CPN) in the Rat: Review of Pathology and Relationship to Renal Tumorigenesis. J. Toxicol. Pathol. 2008. Vol. 21: 199–205.
  13. SEER Cancer Statistics Review, 1975–2003. Surveillance Epidemiology and End Results (SEER). National Cancer Institute. 2006. [E`lektronnyy resurs]: [sayt]. Rezhim dostupa: https://seer.cancer.gov/csr/1975_2003/ - 05.10.2017
  14. Tucker M. J. Diseases of the Wistar Rat. Taylor and Francis, London. 1997: 254 pp.

You may be interested