Peptic ulcer of the stomach and duodenum is a chronic recurrent disease that occurs with alternating periods of recrudescence and remission. The main manifestation of this disease is the formation of a defect in the wall of the stomach and duodenum.
This article presents the results of the study and analysis of reference intervals of biochemical parameters of the blood of mice – one of the key test systems used at the preclinical stage of drug research.
Today, scientists around the world are paying more and more attention to the principles of 3 “Rs” when working with laboratory animals.
Summary. Assessment of mutagenic properties of a new drug is an important part of its preclinical trials, because allows to study the drug’s ability to induce different mutations in fetal and somatic cells.
Tetrachloromethane is actively used to simulate pathologies of the liver, as well as other organs, due to its acute toxic effect, leading to systemic endotoxicosis.
Summary. An instrumental method/device for detecting of estrous stages in small rodents was tested in mice and rats. Cyclic changes in active resistance (RS) of the epithelial cell layer of vaginal mucosa were studied with a new mouse estrous detector device - MED-PRO 100 (Elmi Ltd., Latvia).
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