Passive immunization, proposed by E. Behring, is still a sought-after treatment option using mammalian antibodies. This principle was developed by F. Klemperer in 1893, showing that antibodies that could inactivate the pathogen appeared in the egg yolks of chickens immunized with tetanus toxin.
The scientific and industrial focus of biomedical research using pathogenic biological agents requires a serious comprehensive approach to meeting biological safety requirements. Risk assessment is at the heart of biosafety practice.
Today, one of the main reasons for the spread of insulin resistance, which subsequently leads to the development of obesity, type 2 diabetes and metabolic syndrome (MS), is the peculiarity of modern human eating behavior, its propensity to unlimited intake of high-calorie food.
This paper shows the approbation of the Failure Mode and Effects Analysis (FMEA) method in a preclinical center to determine the risk of zooanthroponotic diseases characteristic of laboratory mini pigs (LMP). Animal experiments are used in many biomedical research, including pharmaceutical.
Pathophysiological reactions of the «mitotondrial cascade» are an important component of the pathogenesis of neurodegenerative diseases, in particular Alzheimer’s disease, and can serve as a basis for neuroprotective intervention, which suggests the relevance of their study.