Diet-Induced Models Of Metabolic Disturbances. Report 2: Experimental Obesity

M. Makarova, Director, V. Makarov, Doctor of Medicine, prof., Deputy dir. of science JSC «Research-and-manufacturing company «Houm оf Pharmacy» JSC «Research-and-manufacturing company «Houm оf Pharmacy», 188663, Russia, Leningradskiy region, Vsevolozhskiy district, Kuzmolovskiy, st. Zavodskaya, 3. b. 245 Е-mail: makarova.mn@doclinika.ru

Abstract

Obesity, the increase in the incidence of which has been observed in recent years, is a risk factor for cardiovascular diseases, type 2 diabetes and many others, which necessitates the search for means of its prevention and treatment. Obesity, both in humans and animals, is based on excessive nutrition and insufficient physical activity, so experimental models in animals (rodents, mini-pigs, etc.) allow to simulate quite accurately the picture of the disease. Given the etiology of obesity, the closest to humans are diet-induced obesity models, among which the most effective are high-fat, less effective are high-fat and carbohydrate combined models; high-carb and low-fat models are little effective. To accelerate the development of obesity it is necessary to use hypokinesia, increase the dark period in vivarium, the use of Mature animals and other measures. Evaluation of the effectiveness of the studied therapeutic and preventive measures in animals with obesity should be carried out with the help of anthropometric indicators (length and body weight, abdomen circumference, Shin length, etc.), evaluation of body weight and fat in them, as well as physiological (blood pressure, etc.) and biochemical parameters (leptin, ghrelin, insulin resistance, adiponectin, etc.).

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