Makarova M.

Summary. Assessment of mutagenic properties of a new drug is an important part of its preclinical trials, because allows to study the drug’s ability to induce different mutations in fetal and somatic cells.

The purpose was to assess Danio rerio behavioral effects for dose-dependent effects of phenazepam, a benzodiazepine anxiolytic. Previously, Danio rerio showed the effects of other anxiolytics, diazepam and chlordiazepoxide.

The pancreas is an unpaired parenchymal organ that belongs to the glands of mixed secretion. It includes the exocrine and endocrine parts, while participating in digestion, and in the regulation of carbohydrate, protein and fat metabolism in tissues.

Summary. According to OECD Test No: 406, the necessary research for drug registration for skin application is the study of the sensitizing potential in the Magnusson and Kligman maximization test (adjuvant test) and Bühler (non-adjuvant test).