Makarova M.

The aim of this work was to test the histological criteria for assessing changes in joints and to conduct a comparative analysis of two experimental models of chronic arthritis in the rat.

When an influence of various toxic substances or prospective medicines on an organism is estimated, the concentration of the substance in question in tissues must be evaluated.

To date, there are two ways to register a reproduced drug (generic) on the pharmaceutical market in terms of preclinical studies: presenting reviews of preclinical and clinical studies of the original drug or reports on the conducted preclinical studies (acute and subacute toxicity of the generic