The pancreas is an unpaired parenchymal organ that belongs to the glands of mixed secretion. It includes the exocrine and endocrine parts, while participating in digestion, and in the regulation of carbohydrate, protein and fat metabolism in tissues. The work of the pancreas obeys a fine neuro-humoral regulation, and its lesions lead to serious consequences. In pre-clinical studies, different types of laboratory animals are used, the pancreas of which in its structure and function is extremely similar to the human. However, there are differences that can have a significant effect on the result obtained in the experiment. In this comparative study, we tried to identify the similarities and differences in organ morphology in humans and laboratory animals. As a result of the analysis of the literature data, the basic similarities in the structure of the human pancreas and laboratory animals, both in anatomical and histological structure, were determined. The pancreas has the same source and patterns of development. The anatomical structure of the pancreas is different: a compact type in humans, in animals it belongs to the mesenteric type. Although the opinions of the authors in this matter are different. Despite this, each species in the pancreas is distinguished by the head, body and tail. The opinion of the researchers varies in the number of ducts in different animals. In the literature there are several variants of the duct system in animals. The histological structure of the pancreas is also of the same type. Exocrine part does not have significant features in different species. In the structure of the islet apparatus (islets of langerhans), it is possible to distinguish specific differences in the qualitative and quantitative composition of the insulocytes. This article can be useful not only for pharmacologists and toxicologists working in preclinical research, but also for histologists, physiologists and pathologists studying the pathology and physiology of the pancreas.
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