Zootechny of laboratory gerbils

Review

УДК 636.028
DOI: 10.57034/2618723X-2024-01-02

T.G. Barmina*,
Animal technician,
https://orcid.org/0000-0002-7807-0768
M.A. Akimova,
Chief animal technician,
https://orcid.org/0000-0001-8643-3613
E.V. Vesnina,
Animal maintenance technician,
https://orcid.org/0000-0003-4876-1397
D.Y. Akimov,
Chief veterinarian,
https://orcid.org/0000-0003-3141-492X

Research and manufacturing company “Home оf Pharmacy”,
188663, Russia, Leningrad oblast, Vsevolozhskiy district, Kuzmolovskiy t.s., Zavodskaya st. 3–245.

* E-mail: [email protected]


Keywords: laboratory animals gerbils maintenance reproduction feeding

Acknowledgements

The study was performed without external funding.


For citation:

Barmina T.G., Akimova M.A., Vesnina E.V., Akimov D.Yu. Zootechny of laboratory gerbils. Laboratory Animals for Science. 2024; 1. https://doi.org/10.57034/2618723X-2024-01-02

Abstract

For the maintenance of laboratory gerbils, which are a valuable test system in preclinical studies, it is necessary to pay attention to such zootechnical parameters as the conditions of their placement, taking into account the parameters of the microclimate, feeding rations appropriate to their needs, as well as options for providing environmental enrichment. An important process in the maintenance of this type of animal is the selection and provision of a suitable enrichment environment in order to reduce their stress and anxiety levels. In order to maintain the number of available gerbils or increase it, it is necessary to take into account their reproductive indicators, as well as species characteristics when composing parental pairs. To carry out a traditional analysis of the scientific literature on the zootechny of laboratory gerbils. The search for publications was performed in the PubMed and Google Scholar databases. The review included searchable publications as of September 11, 2023. In this review, the main aspects of keeping gerbils were identified, namely: optimal floor area, frequency of cell replacement, as well as features of proper animal capture, optimal microclimate conditions (permissible temperature, humidity, ventilation and lighting conditions), types of environmental enrichment, feeding and watering of animals depending on their age and physiological conditions, as well as reproductive indicators of gerbils, including features of the selection of parental pairs. When analyzing the literature data, the main recommendations on the maintenance of gerbils were collected, taking into account all zootechnical needs for their placement and reproduction.

Conflict of interest

The authors declare no conflict of interest.

Authors contribution

T.G. Barmina — collection of scientific literature data, writing and editing of the text, preparation of the final version of the article for publication.
M.A. Akimova — search of literature data, working with tabular material, writing the conclusion.
E.V. Vesnina — work with literary sources, preparation of the drawing.
D.Y. Akimov — critical review and approval of the final version of the manuscript for publication.

  1. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes Text with EEA relevance.

References

  1. Cheal M. The gerbil: A unique model for research on aging // Experimental Aging Research. 1986. Vol. 12. N. 1. P. 3–21. DOI: 10.1080/03610738608259430.
  2. Mulder G.B., Pritchett-Corning K.R., Gramlich M.A. et al. Method of feed presentation affects the growth of Mongolian gerbils (Meriones unguiculatus) // Journal of the Ame­rican Association for Laboratory Animal Science: JAALAS. 2010. Vol. 49. N. 1. P. 36–39.
  3. National Research Council et al. Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. 2011.
  4. Code of Practice for the Housing and Care of Animals Bred, Supplied Or Used for Scientific Purposes. Great Britain, Stationery Office, 2014. Р. 212.
  5. McCullagh E.A., McCullagh P., Klug A. et al. Effects of an Extended Cage-change Interval on Ammonia Levels and Reproduction in Mongolian Gerbils (Meriones unguiculatus) // Journal of the American Association for Laboratory Animal Science. 2017. Vol. 56. N. 6. P. 713–717.
  6. Van Zutphen L.F. M., Baumans V., Beynen A.C. Principles of Laboratory Animal Science. Amsterdam: Elsevier Science, 2001. 416 p.
  7. Рыбакова А.В., Макарова М.Н. Зоотехнические характеристики содержания песчанок в экспериментальных вивариях // Лабораторные животные для научных исследований. 2018. № 2. [Rybakova A.V., Makarova M.N. Zootekhnicheskiye kharakteristiki soderzhaniya peschanok v eksperimental’nykh vivariyakh // Laboratornyye zhivotnyye dlya nauchnykh issledovaniy. 2022. N. 2. (In Russ.)]. DOI: 10.29296/2618723X-2018-02-03.
  8. Thiessen D.D. Body temperature and grooming in the Mongolian gerbil // Annals of the New York Academy of Sciences. 1988. N. 525. P. 27–39. DOI: 10.1111/j.1749-6632.1988.tb38593.x.
  9. Canadian Council on Animal Care: Guide to the Care and Use of Experimental Animals. 1984. Vol. 2.
  10. Keeble E., Meredith А. Manual of Rodents and Ferrets. BSAVA. 2013. 392 p.
  11. Kaplan H., Miezejeski C. Development of seizures in the mongolian gerbil (Meriones unguiculatus) // Journal of compa­rative and physiological psychology. 1972. Vol. 81. N. 2. P. 267–273. DOI: 10.1037/h0033517.
  12. Batchelder M., Keller L.S., Sauer M.B. et al. Gerbils // The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. 2012. P. 1131–1155. DOI: 10.1016/B978-0-12-380920-9.00052-3.
  13. Waiblinger E., König B. Refinement of gerbil housing and husbandry in the laboratory // Alternatives to laboratory animals. 2004. Vol. 32. N. 1. P. 163–169. DOI: 10.1177/026119290403201s27.
  14. Baumans V. Environmental Enrichment for Laboratory Rodents and Rabbits: Requirements of Rodents, Rabbits, and Research // ILAR Journal. 2005. Vol. 46. N. 2. P. 162–170. DOI: 10.1093/ilar.46.2.162.
  15. Waiblinger E., König B. Housing and husbandry conditions affect stereotypic behaviour in laboratory gerbils // ALTEX. 2007. Vol. 24. P. 67–69.
  16. National Research Council. Nutrient Requirements of Laboratory Animals. Washington: National Academies Press, 1995.
  17. Бондарева Е.Д., Акимова М.А., Веснина Е.В. Рекомендуемые способы поения лабораторных животных. Технические особенности. Обеспечение благополучия и здоровья лабораторных животных // Лабораторные животные для научных исследований. 2022. № 2. [Bonda­reva Ye.D., Akimova M.A., Vesnina Ye.V. Rekomenduyemyye znacheniya dlya laboratornykh issledovaniy zhivotnykh. Tekhnicheskiye osobennosti. Povysheniye urovnya zhizni i zdorov’ya laboratornykh zhivotnykh // Labo­ratornyye zhivotnyye dlya nauchnykh issledovaniy. 2022. N. 2. (In Russ.)]. DOI: 10.29296/2618723X-2022-02-08.
  18. Norris M.L., Adams C.E. Aggressive behaviour and reproduction in the mongolian gerbil, Meriones unguiculatus, relative to age and sexual experience at pairing // Journal of reproduction and fertility. 1972. Vol. 31. N. 3. P. 447–450. DOI: 10.1530/jrf.0.0310447.
  19. Kubiak M. Mongolian Gerbils. Handbook of Exotic Pet Medi­cine. 2020. P. 71–82. DOI: 10.1002/9781119389934.ch6.
  20. Barfield M.A., Beeman E.A. The oestrous cycle in the mongolian gerbil, meriones unguiculatus // Journal of reproduction and fertility. 1968. Vol. 17. N. 2. P. 247–251. DOI: 10.1530/jrf.0.0170247.
  21. Bagwell J.N., Leavitt W.W. Prenatal size-age relationships and external morphology in the Mongolian gerbil (Meriones unguiculatus) // The American journal of anatomy. 1974. Vol. 140. N. 1. P. 117–127. DOI: 10.1002/aja.1001400108.
  22. Salo A.L., French J.A. Early experience, reproductive success, and development of parental behaviour in Mongolian gerbils // Animal Behaviour. 1989. Vol. 38. N. 4. P. 693–702. DOI: 10.1016/S0003-3472(89)80015-6.
  23. Kai O., Sakemi K., Suzuki Y. et al. Effects of age at first-pai­ring on the reproductive performance of Mongolian gerbils (Meriones unguiculatus) // Experimental animals. 1995. Vol. 44. N. 4. P. 307–313. DOI: 10.1538/expanim.44.307.
  24. Elwood R.W., Broom D.M. The influence of litter size and parental behaviour on the development of Mongolian gerbil pups // Animal Behaviour. 1978. Vol. 26. P. 438–454. DOI: 10.1016/0003-3472(78)90061-1.
  25. Saltzman W., Ahmed S., Fahimi A. et al. Social suppression of female reproductive maturation and infanticidal behavior in cooperatively breeding Mongolian gerbils // Hormones and behavior. 2006. Vol. 49. N. 4. P. 527–537. DOI: 10.1016/j.yhbeh.2005.11.004.
  26. Wallace P., Owen K., Thiessen D.D. The control and function of maternal scent marking in the Mongolian gerbil // Physiology and Behavior. 1973. Vol. 10. N. 3. P. 463–466. DOI: 10.1016/0031-9384(73)90206-0.
  27. Yahr P., Thiessen D.D. Estrogen control of scent mar­king in female mongolian gerbils (Meriones unguiculatus) // Behavioral Biology. 1975. Vol. 13. N. 1. P. 95–101. DOI: 10.1016/S0091-6773(75)90838-X.
  28. Payman B.C., Swanson H.H. Social influence on sexual ma­turation and breeding in the female Mongolian gerbil (Me­riones unguiculatus) // Animal Behaviour. 1980. Vol. 28. N. 2. P. 528–535. DOI: 10.1016/S0003-3472(80)80061-3.
  29. Clark M.M., Galef B.G. Socially induced infertility: familial effects on reproductive development of female Mongolian gerbils // Animal Behaviour. 2001. Vol. 62. N. 5. P. 897–903. DOI: 10.1006/anbe.2001.1827.
  30. Saltzman W., Thinda S., Higgins A.L. et al. Effects of siblings on reproductive maturation and infanticidal behavior in cooperatively breeding Mongolian gerbils // Developmental psychobiology. 2009. Vol. 51. N. 1. P. 60–72. DOI: 10.1002/dev.20347.

Received: 2023-12-27
Reviewed: 2024-02-12
Accepted for publication: 2024-02-26

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