To date, there are two ways to register a reproduced drug (generic) on the pharmaceutical market in terms of preclinical studies: presenting reviews of preclinical and clinical studies of the original drug or reports on the conducted preclinical studies (acute and subacute toxicity of the generic
Obesity, the increase in the incidence of which has been observed in recent years, is a risk factor for cardiovascular diseases, type 2 diabetes and many others, which necessitates the search for means of its prevention and treatment.
The research and development of new drugs for the treatment and prevention of non-alcoholic steatohepatitis (NASH) is one of the urgent problems of modern pharmacology. NASH represents a significant threat to health, so its development occurs gradually, without pronounced manifestations.
The fourth message from the series of articles on the methodology of necropsy and extraction organs of laboratory animals, describing in detail and illustrating the technique of sequential and complete autopsy and extraction of organs of laboratory guinea pigs, gerbils and degu.
Respiratory organs provide the gas exchange function in which various pathogenic substance and microorganisms causing respiratory diseases can enter the organism and settle in the epithelial surface of lungs and airway tracts.
Fixation of organs and tissues precedes the direct preparation of histological preparations. The quality of fixation affects the achievement of microscopic research, so it is very important to choose the most optimal methods of fixation individually.
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