The purpose was to assess Danio rerio behavioral effects for dose-dependent effects of phenazepam, a benzodiazepine anxiolytic. Previously, Danio rerio showed the effects of other anxiolytics, diazepam and chlordiazepoxide.
According to the analysis of scientific literature, it has been shown that pigs are the optimal biological object among laboratory animals for the assessment of cognitive impairment caused by various pharmaceutical substances of medicinal agents.
The aim of this study was to evaluate the behavior of mice of two inbred strains C57Bl/6 and BALB/c in the “open field” test, as well as the effect of the drug with anxiolytic activity Lyrica® (INN: pregabalin) on their behavior under test conditions.
When planning and conducting preclinical research, it is important for researchers to obtain reliable and up-to-date information not only about the design of research, but also about the welfare of animals in the study, mice keeping, information about methods of eutha