Dependence Of Liquid Intake In Laboratory Mice From Diet

DOI: 10.29296/2618723X-2018-03-10

M.V. Lopatina, E.N. Petritskaya, A.L. Ivlieva Moscow regional Clinical Research Institute. M. f. Vladimirsky Moscow Russia St. Schepkina 61/2, 129110 E-mail: [email protected]

Keywords: laboratory animals liquid intake diet mixed fodder fresh food

For citation:

Lopatina M.V., Petritskaya E.N., Ivlieva A.L. Dependence Of Liquid Intake In Laboratory Mice From Diet. Laboratory Animals for Science. 2018; 3. https://doi.org/10.29296/2618723X-2018-03-10

Abstract

With the experimental setup in which the test substance is taken by laboratory animals as a drinking solution, it is necessary to take into account the possibility of influence of the composition of their diet on the intake of liquid in order to calculate the amount of the substance that has entered the body. The amount of liquid consumed by the animal was calculated to assess the average daily liquid intake by intact animals depending on the type of feeding: fresh food and grain or only mixed fodder. Two equal groups of mice were compiled: the first group received mixed fodder, and the second group - fresh vegetables and grains. The consumption of liquid by the animals which had been receiving mixed fodder containing little water, exceeded that of those fed with fresh food almost twice, even in the absence of any factors that affect animals, except for the diet. Consequently, the dependence of liquid intake on the diet can significantly affect the amount of intake of the dissolved test substance into the body, which may affect the interpretation of the effects of its influence.

References

GOST 33216-2014. Rukovodstvo po soderzhaniyu i uhodu za laboratornymi zhivotnymi. Pravila soderzhaniya i uhoda za laboratornymi gryzunami i krolikami. Vved. 2016-07-01. M.: FGUP Standartinform, 2014: 10.
Zapadnyuk I.P., Zapadnyuk V.I., Zahariya V.A. Laboratornye zhivotnye, ih razvedenie, soderzhanie i ispol`zovanie v e`ksperimente. – Kiev: Gos. med. izd-vo USSR, 1962: 350.

You may be interested

Model of diet-induced experimental diabetes mellitus in laboratory gerbils and degus
According to the latest data from the International Diabetes Federation (IDF), the number of patients with diabetes has outpaced previously predicted growth rates and is expected to increase by 51% by 2045.
Experience with an optimized methodology of safety studies for pediatric medicines using the example of a drug containing cattle cerebral cortex polypeptides
This article presented the results of an experimental preclinical toxicological study of the drug containing cattle cerebral cortex polypeptides concerning the health indicators of immature animals.
Allergy to laboratory rodents: the underestimated problem
In the present review, we discuss the problem of hypersensitivity to laboratory animal allergens, which affects both animal caretakers and research personnel. Biological characteristics of the main allergens released by laboratory rodents are presented, as well a
Application of morphometry methods to assess histopathology in preclinical studies
Morphometry is one of the most important methods of preclinical studies. It is an integral part of microscopy analysis.
Zootechny of laboratory gerbils
For the maintenance of laboratory gerbils, which are a valuable test system in preclinical studies, it is necessary to pay attention to such zootechnical parameters as the conditions of their placement, taking into account the parameters of the microclimate, feeding rations appropriate to their n
The methods of visualization and research of the git-associated lymphoid tissue of laboratory animals
The immune system is an important part of the vital activity in the organism, because it prevents a penetration of foreign bodies and substances or it deletes them very quickly.

Dependence Of Liquid Intake In Laboratory Mice From Diet

Abstract

References

Search

You may be interested