Белопольская М.В.

Severity assessment of scientific procedures performed on laboratory animals. Theoretical and applied aspects

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The Practice Of Modeling Pyoinflammatory Wounds At The Immunosuppression
Summary. Treatment of purulent complications of soft tissues is one of the most common problems in medical practice presently.
Clinical, biochemical and pathomorphological features of direct acute lung injury in rats caused by intratracheal administration of Salmonella enterica lipopolysaccharide
The aim of this study was to assess the clinical, biochemical and pathomorphological features of direct acute lung injury (ALI) in rats caused by intratracheal (i/t) administration of Salmonella enterica lipopolysaccharide at a dose of 20 mg/kg (LD₅₀).
Differences in the behavior of two line C57BL/6 and BALB/C mice in the "open field" test in the background of pregabalin
The aim of this study was to evaluate the behavior of mice of two inbred strains C57Bl/6 and BALB/c in the “open field” test, as well as the effect of the drug with anxiolytic activity Lyrica^® (INN: pregabalin) on their behavior under test conditions.
Approbation of the cisplatin-induced acute vomiting model in ferret and choice of reference treatment
The absent of effective in all clinical and other conditions nausea and vomiting antiemetic treatment demonstrate the need for research in this area. This raises the question, what models are most suitable for such studies.
Behavioural and reproductive characteristics of heterozygous TPH2 knockout mice
TPH2 mutant mice are a highly accurate model for several mental illnesses such as autism, attention deficit disorder, and obsessive-compulsive and depressive disorders.
Some specific features of the anatomy of the hepatobiliary system and the composition of bile in laboratory animals
Bile acids are important signaling molecules involved in the regulation of lipid and glucose metabolism, maintenance of metabolic and energy homeostasis. Mice, rats, guinea pigs and rabbits are used as model organisms in pharmacodynamic studies.

Белопольская М.В.

Severity assessment of scientific procedures performed on laboratory animals. Theoretical and applied aspects

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