Although animal pain models may be highly sensitive to small changes in animal care, all relevant details are usually not reported in research papers, potentially resulting in increased inter-laboratory variability.
The aim of this study was to evaluate the behavior of mice of two inbred strains C57Bl/6 and BALB/c in the “open field” test, as well as the effect of the drug with anxiolytic activity Lyrica® (INN: pregabalin) on their behavior under test conditions.
To date, there are two ways to register a reproduced drug (generic) on the pharmaceutical market in terms of preclinical studies: presenting reviews of preclinical and clinical studies of the original drug or reports on the conducted preclinical studies (acute and subacute toxicity of the generic
Today there are very strict rules for toxicological studies of chemicals, including drugs. Traditionally, it includes animal studies. At the same time, public opinion and government initiatives based on it keep suggesting reducing the number of animals in research.
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