Афанасьева А.Н.

Optimal choice method of detection of the viability of cell cultures for tests on proliferation and cytotoxicity

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Assessment of the risk of zooanthroponose diseases and diseases characteristic for laboratory dymp pigs in the conditions of the preclinical center
This paper shows the approbation of the Failure Mode and Effects Analysis (FMEA) method in a preclinical center to determine the risk of zooanthroponotic diseases characteristic of laboratory mini pigs (LMP). Animal experiments are used in many biomedical research, including pharmaceutical.
Variability of blood biochemical parameters and establishing of reference ranges in nonclinical studies. Part 1: rats
Establishing of current reference ranges for laboratory animal parameters is topical problem both in clinical and nonclinical studies. Retrospective analysis of 11 serum biochemical parameters in rats was conducted.
QUANTITATIVE ESTIMATION OF URINE SEDIMENT IN HEALTHY WISTAR RATS
No biological experiment is carried out without the participation of laboratory animals, while rats are most often used, which are a stable model that allows you to reproduce various pathological processes.
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C57BL/6J mice are widely used in various medical and biological studies. However, characteristic increase of sex hormones in the males’ blood in response to a sexual stimulus was not detected.
Approbation of the cisplatin-induced acute vomiting model in ferret and choice of reference treatment
The absent of effective in all clinical and other conditions nausea and vomiting antiemetic treatment demonstrate the need for research in this area. This raises the question, what models are most suitable for such studies.
Analysis of Bacillus spp. in the diet and feces of laboratory mice under barrier-housing and non-sterile conditions
Сurrently, the standard for housing laboratory animals is barrier vivariums, which ensure the sterility of conditions for environment and diet.

Афанасьева А.Н.

Optimal choice method of detection of the viability of cell cultures for tests on proliferation and cytotoxicity

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