Kirichenko D.V.

The article provides an overview of the most significant works of domestic and foreign authors devoted to the Ehrlich ascites carcinoma biological model.

Cadmium is a heavy metal, highly toxic pollutant, entering the environment as a by-product of most modern industries. The effect of cadmium on the body depends on the route of entry, duration and dose of exposure.

This model is used to evaluate the inhibitory activity of drugs aimed at vascular permeability normalization. The barrier function of endothelium is disrupted on some pathologies.

Burns are a severe and widespread type of injury and are accompanied by local and systemic complications, leading to disability and death.

Currently streptozotocin (STZ) is the most common diabetogenic substance used to model experimental diabetes mellitus on different types of laboratory animals during last 50 years.

Although animal pain models may be highly sensitive to small changes in animal care, all relevant details are usually not reported in research papers, potentially resulting in increased inter-laboratory variability.