Features of the reproduction of marmosets or common igrunka

Review
УДК 636.978
DOI: 10.57034/2618723X-2023-01-08

D.Yu. Akimov*,
сhief veterinarian,
https://orcid.org/0000-0003-3141-492X
T.G. Barmina,
animal technician,
https://orcid.org/0000-0002-7807-0768

Research and manufacturing company “Home оf Pharmacy”,
188663, Russia, Leningrad oblast, Vsevolozhskiy district, Kuzmolovskiy t.s., Zavodskaya st. 3–245.

* Е-mail: [email protected]

Keywords: Callithrix jacchus reproduction reproductive system breeding hormones
Acknowledgements

The study was performed without external funding.

For citation:

Akimov D.Yu., Barmina T.G. Features of the reproduction of marmosets or common igrunka. Laboratory Animals for Science. 2023; 1. https://doi.org/10.57034/2618723X-2023-01-08

Abstract

Due to the boost in the production of biotechnological products and gene therapy, the use of non-human primates in preclinical studies has increased, since they are often the only species which show a reliable result of researched objects. Thus, today Callithrix jacchus is an important object of research in the field of biology, assessment of immunological and toxicological safety, diagnosis of diseases, development and quality control of products and devices in medicine, dentistry and veterinary medicine.

To conduct preclinical studies, it is often necessary to start breeding animals. The Callithrix jacchus is one of those animals whose reproduction system requires special attention, knowledge and certain conditions.

Marmosets (lat. Callitrichidae) are a family of small primates belonging to the broad-nosed monkeys of the New World.

This review describes the reproduction of monkeys from the population level up to the molecular level considering the social roles of animals in groups, the physiological characteristics of females’ and males’ bodies, as well as the influence of external factors. The whole picture of animal reproduction allows predicting and planning further production processes, ensuring the well-being of livestock and healthy offspring.

The purpose of the review is to indicate monkeys’ reproductive potential, to determine behavioral characteristics and social roles in groups, to consider the physiological aspects of the reproductive system at all levels of the organization.

To achieve this goal, the following tasks were identified:
1) Search for literature data on the peculiarities of the reproductive system of male and female marmosets;
2) Generalization and systematization of the data obtained.

As a result, the following was summarized and described:

  • main males’ and females’ physiological parameters were determined;
  • female marmosets’ first fertilization timing was established;
  • behavioral characteristics of males and females during the breeding season were analyzed;
  • idea of the hypothalamic-pituitary-gonadal axis of males and females was described;
  • proliferation processes of germ cells, the dynamics of the levels of the main sex hormones depending on the cycle and their effect on the body are considered.

Conflict of interest

The authors declare no conflict of interest requiring disclosure in this article.

Authors contribution

All authors took active part in the discussion of the results and writing of the text.

References

  1. Albert S., Wistuba J., Eildermann K. et al. Comparative marker analysis after isolation and culture of testicular cells from the immature marmoset // Cells Tissues Organs. 2012. Vol. 196. N. 6. Р. 543–554.
  2. Donna G., Layne D.G., Power R.A. Husbandry, Handling, and Nutrition for Marmosets // Comparative Medicine. 2003. Vol. 53. N. 4. Р. 351–359.
  3. Caro Т.M., Sellen D.W., Parish A. et al. Termination of reproduction in nonhuman and human female primates // International Journal of Primatology. 1995. Vol. 16. N. 2. Р. 205–220.
  4. Cui K.H. The effect of stress on semen reduction in the marmoset monkey (Callithrix jacchus) // Human Reproduction. 1996. Vol. 11. N. 3. Р. 568–573.
  5. Yoshimoto T., Takahashi E., Yamashita S. et al. Larger cages with housing unit environment enrichment improve the welfare of marmosets // Experimental Animals. 2018. Vol. 67. N. 1. Р. 31–39.
  6. Акимов Д.Ю., Макарова М.Н., Акимова М.А., Бондарева Е.Д., Хан С.О. Риск-ориентированный подход к проведению мониторинга здоровья обезьян // Лабораторные животные для научных исследований. 2021. № 2. С. 69–82. [Akimov D.Yu., Makarova M.N., Akimova M.A., Bondareva E.D., Khan S.O. Risk-based approach to the health monitoring of primates // Laboratory Animals for Science. 2021. N. 2. P. 69–82. (In Russ.)]. DOI: 10.29296/2618723X-2021‑02‑09.
  7. National Research Council (US) Committee on Well-Being of Nonhuman Primates. The Psychological Well-Being of Nonhuman Primates. National Academies Press, 1998. 168 р.
  8. Abbott D.H., Hearn J.P. Physical, hormonal and behavioural aspects of sexual development in the marmoset monkey, Callithrix jacchus // Journal of reproduction and fertility. 1978. Vol. 53. N. 1. Р. 155–166.
  9. Dixson A.F. Medial hypothalamic lesions and sexual receptivity in the female common marmoset (Callithrix jacchus) // Folia Primatologia. 1990. Vol. 54. N. 1–2. P. 46–56.
  10. Dixson A.F. Effects of adrenalectomy upon proceptivity, receptivity and sexual attractiveness in ovariectomized marmosets (Callithrix jacchus) // Physiology & behavior. 1987. Vol. 39. N. 4. P. 495–559.
  11. Martin R.D. Primate Origins and Evolution: A Phylogenetic Reconstruction // International Journal of Primatology. 1990. Vol. 12. Р. 77–79.
  12. Rowell T.E. Female reproductive cycles and social behavior in primates // Advances in the Study of Behavior. 1972. Vol. 4. P. 69–105.
  13. Harvey P.H., Martin R.D., Clutton-Brock T.H. Primate Societies. University of Chicago Press, 1987. 578 р.
  14. Hearn J.P., Abbott D.H., Chambers P.C. et al. Use of the common marmoset, Callithrix jacchus, in reproductive research // Primates in Medicine. 1978. Vol. 10. Р. 40–49.
  15. Dixson A.F. Primate Sexuality: Comparative Studies of the Prosimians, Monkeys, Apes, and Human Beings // International Journal of Primatology. 2012. Vol. 34. N. 1. Р. 216–218.
  16. Tardif S., Carville A., Elmore D. et al. Reproduction and Breeding of Nonhuman Primates // Nonhuman Primates in Biomedical Research. 2012. Р. 197–249.
  17. Einspanier A., Gore M.A. Reproduction: Definition of a Primate Model of Female Fertility // The Laboratory Primate. 2005. Р. 105–117.
  18. Фридман Э.П. Занимательная приматология. 1985. 180 с. [Fridman E.P. Zanimatel’naya primatologiya. 1985. 180 p. (In Russ.)].
  19. Bauer C. The baboon (Papio sp.) as a model for female reproduction studies // Contraception. 2015. Vol. 92. N. 2. P. 120–123. DOI: 10.1016/j.contraception.2015.06.007.
  20. Bronson F.H. Mammalian Reproductive Biology. The University of Chicago Press, 1989. 336 р.
  21. Rowe N. The Pictorial Guide to the Living Primate. Pogonias Press, 1996. 263 р.
  22. Power M.L., Ross C.N., Schulkin J. et al. Metabolic consequences of the early onset of obesity in common marmoset monkeys // Obesity. 2013. Vol. 21. N. 12. Р. 592–598.
  23. Wolfe-Coote S. The Laboratory Primate: The Handbook of Experimental Animals. Elsevier Academic Press, 2005. 621 р.
  24. Hodges J.K., Eastman S.A.K. Monitoring ovarian function in marmosets and tamarins by the measurement of urinary estrogen metabolites // American journal of Primatology. 1984. Vol. 6. Р. 187–197.
  25. Eastman S.A., Makawiti D.W., Collins W.P. et al. Pattern of excretion of urinary steroid metabolites during the ovarian cycle and pregnancy in the marmoset monkey // Journal of Endocrinology. 1984. Vol. 102. N. 1. Р. 19–26.
  26. Einspanier A., Nubbemeyer R., Schlote S. et al. Relaxin in the marmoset monkey: secretion pattern in the ova­rian cycle and early pregnancy // Biology of Reproduction. 1999. Vol. 61. N. 2. Р. 512–520.
  27. Norman R.L., Lindstrom S.A., Bangsberg D. et al. Pulsatile secretion of luteinizing hormone during the menstrual cycle of rhesus macaques // Endocrinology. 1984. Vol. 115. N. 1. Р. 261–266.
  28. Gilchrist R.B., Wicherek M., Heistermann M. et al. Changes in follicle-stimulating hormone and follicle populations during the ovarian cycle of the common Marmoset // Biology of Reproduction. 2001. Vol. 64. N. 1. P. 127–135.
  29. Plant T.M., Gay V.L., Marshall G.R. et al. Puberty in monkeys is triggered by chemical stimulation of the hypothalamus // Proceedings of the National Academy of Scien­ces of the United States of America. 1989. Vol. 86. N. 7. Р. 2506–2510.
  30. Plant T.M., Marshall G.R. The functional significance of FSH in spermatogenesis and the control of its secretion in male primates // Endocrine reviews. 2001. Vol. 22. N. 6. Р. 764–786.
  31. Nieschlag E., Simoni M., Gromoll J. et al. Role of FSH in the regulation of spermatogenesis: clinical aspects // Clinical endocrinology. 1999. Vol. 51. N. 2. Р. 139–146.
  32. Cui K.H., Matthews C.D. Anatomy of adult female common marmoset (Callithrix jacchus) reproductive system // Journal of anatomy. 1994. Vol. 185. Р. 481–486.
  33. Stein F.J. Sex determination in the common marmoset (Callithrix jacchus) // Laboratory animal science. 1978. Vol. 28. N. 1. Р. 75–80.
  34. Слободяник В.С., Сулейманов С.М., Антипова Л.В. Анатомия и гистология сельскохозяйственных животных, 2‑е изд. Москва: Юрайт, 2019. 387 с. [Slobodyanik V.S., Suleymanov S.M., Antipova L.V. Anatomiya i gistologiya sel’skokhozyaystvennykh zhivotnykh, 2‑ye izd. Moskva: Yurayt, 2019. 387 р. (In Russ.)].
  35. Moudgal N.R., Sairam M.R. Is there a true requirement for follicle stimulating hormone in promoting spermatogenesis and fertility in primates? // Human reproduction. 1998. Vol. 13. N. 4. Р. 916–919.
  36. Orth J.M., Gunsalus G.L., Lamperti A.A. Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development // Endocrino­logy. 1988. Vol. 122. N. 3. Р. 787–794.
  37. Millar M.R., Sharpe R.M., Weinbauer G.F. et al. Marmoset spermatogenesis: organizational similarities to the human // International journal of andrology. 2000. Vol. 23. N. 5. Р. 266–277.
  38. Weinbauer G.F., Aslam H., Krishnamurthy H. et al. Quantitative analysis of spermatogenesis and apoptosis in the common marmoset (Callithrix jacchus) reveals high rates of spermatogonial turnover and high spermatogenic efficiency // Biology of reproduction. 2001. Vol. 64. N. 1. Р. 120–126.
  39. Worley K.C., Warren W.C., Wilson R.K. The common marmoset genome provides insight into primate biology and evolution // Nature Genetics. 2014. Vol. 46. N. 8. Р. 850–857.
Received: 2022-12-12
Reviewed: 2023-02-22
Accepted for publication: 2023-02-27

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