Assessment of the risk of zooanthroponose diseases and diseases characteristic for laboratory dymp pigs in the conditions of the preclinical center

Original article

УДК 616.9-022.39:591.491.2:636.4

DOI: 10.57034/2618723X-2023-01-02

V.A. Berezkin¹,
veterinarian,
https://orcid.org/0000-0002-5557-1287
E.D. Bondareva¹*,
Head of the Biosafety Group,
https://orcid.org/0000-0002-7170-9717
N.A. Semenenko²,
Assistant of the Department of Organization, Economics and Management of Veterinary Business

¹ Research and manufacturing company “Home оf Pharmacy”,
188663, Russia, Leningrad oblast, Vsevolozhskiy district, Kuzmolovskiy t.s., Zavodskaya st. 3–245;
² Veterinary Affairs, Federal Budgetary Educational Institution of Higher Education “St. Petersburg State University of Veterinary Medicine”,
196084, Russia, St. Petersburg, st. Chernigovskaya, 5.

* Е-mail: [email protected]

Keywords: infectious diseases mini pigs anti-epizootic measures laboratory pigs

Acknowledgements

The study was performed without external funding.

For citation:

Berezkin V.А., Bondareva E.D. , Semenenko N.A. Assessment of the risk of zooanthroponose diseases and diseases characteristic for laboratory dymp pigs in the conditions of the preclinical center. Laboratory Animals for Science. 2023; 1. https://doi.org/10.57034/2618723X-2023-01-02

Abstract

This paper shows the approbation of the Failure Mode and Effects Analysis (FMEA) method in a preclinical center to determine the risk of zooanthroponotic diseases characteristic of laboratory mini pigs (LMP). Animal experiments are used in many biomedical research, including pharmaceutical. mini pigs were bred in the 1950s in Germany and were subjected to selective breeding because of their small size, as well as their docile nature. Since then, they have been used as alternative non-rodent animal species in various studies. Laboratory dwarf pigs are highly valued in research because of their genetic similarity to humans. mini pigs serve as a good model for the study of chronic toxicity, immunogenicity, pharmacokinetics, are in demand as an object for the induction of pathology and are widely used in the world. To date, dwarf pigs are actively used for various ophthalmological studies, including studies to assess the safety and effectiveness of eye therapy, etiopathogenesis and treatment of glaucoma, new biomaterials, surgical procedures and implantable materials/devices.

Pigs are a fairly expensive test system and represent social significance, as well as due to the large use of dwarf pigs in laboratory research, the issues of animal health monitoring are being updated. Animal health monitoring is one of the most important stages of the organization of work in the preclinical center. The purpose of this study was to determine the list of zooanthroponotic diseases and diseases characteristic of LCS with an assessment of their risk to personnel and the epizootological situation in the preclinical center using the FMEA methodThe study defined a list of zooanthroponotic diseases of LMP, which consists of 24 diseases, taking into account that diseases such as tetanus, hepatitis E, swine flu, anthrax, gas gangrene, streptococcosis, Aujeszky’s disease, bordetellosis, campylobacteriosis, yersiniosis and Nipah disease are not found on the territory of the Russian Federation. A list of vaccines that are used in the prevention of zooanthroponotic diseases in humans and pygmy pigs has been established. Of the 24 zooanthroponotic diseases, vaccination has not been developed for only 5. It should be noted that almost all vaccines are produced in the Russian Federation.

Conflict of interest

Authors declare no conflict of interest requiring disclosure in this article.

Authors contribution

V.A. Berezkin — data collection and analysis, experimental manipulations, analysis of literature sources, writing the text of the article.
E.D. Bondareva — elaboration of the study idea and justification of its relevance, editing of the text.
N.A. Semenenko — critical revision of the content of the text, analysis of literature sources.

References

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Received: 2022-08-02

Reviewed: 2022-12-30

Accepted for publication: 2023-01-24

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