New in the science and practice of preclinical research

M. Makarova, ORCID 0000-0003-3176-6386.
V. Makarov, ORCID 0000-0002-2447-7888

St. Petersburg Institute of Pharmacy

188663, Russia, Leningradskiy region, Vsevolozhskiy district, Kuzmolovskiy t.s., Zavodskaya st. 3–245



The article provides a brief description of some interesting publications about new research in the science and practice of preclinical research. The results of a study indicating the possibility of using gingival venopuncture as an alternative minimally traumatic method of blood sampling in Guinea pigs for hematological blood analysis are presented.

Another publication gives a comparative assessment of the 6 most commonly used methods of blood sampling in mice (lateral incision of the tail; amputation of the tip of the tail; puncture of the hyoid, submandibular and subcutaneous veins; retrobulbar sinus puncture during anesthesia with isoflurane).

An interesting study is the use of sliders for postoperative protection of rabbits. At the same time, it was shown that they are more successful than collars, both in terms of ensuring adequate social behavior of rabbits, and in terms of healing speed, less trauma to the site of the surgical incision, as well as – more economical.

Another publication is devoted to the evaluation of a new system for keeping laboratory animals, the so-called "individually ventilated cells", which have many advantages over conventional ventilation systems, allowing animals to reduce stress reactions, physiological and hormonal disorders that weaken the health of animals.

Researchers dealing with oral and dental problems will be interested in a publication on the modeling of diet-induced generalized periodontitis in rats and the experimental evaluation of such a model.

Full text avaliable in Russain only

Acknowledgements. The study was performed without external funding.

Authors’ contributions.

Marina N. Makarova – idea. analysis of literature data, compilation of the list of references. writing, revising the text.

Valeriy G. Makarov – data collection and systematization, writing individual parts of the text.



  1. Personett A.R., Santangelo K.S., Kendall L.V., Sadar M.J. Hematologic Parameters and Blood Cultures from the Gingival Vein Compared with the Cranial Vena Cava in Guinea Pigs. J. Amer. Assoc. Lab. Anim. Sci., 2019. – Vol. 58(6). – P. 817-822. Doi: 10.30802/AALAS-JAALAS-19-000039.
  2. Sørensen D.B., Metzdorff S.B., Jensen L.K., Andersen K.H., Teilmann A.C., Jensen H.E., Frøkiaer, H. Time-dependent Pathologic and Inflammatory Consequences of Various Blood Sampling Techniques in Mice. J. Amer. Assoc. Lab. Anim. Sci., 2019. Vol. 58(3). – P. 362–372. Doi:10.30802/aalas-jaalas-18-000064.
  3. Bartley K.A., Johnson C.H. Human Infant Pants for Postoperative Protection during Social Housing of New Zealand White Rabbits (Oryctolagus cuniculus). J. Amer. Assoc. Lab. Anim. Sci., 2019 Vol. 58(4). – P. 510-516. Doi: 10.30802/AALAS-JAALAS-18-000116.
  4. Wang X., Zhang Y., Lu T., Qi J., Liu H., Jin Z., Chen H. The effect of cage ventilation rate on the health of mice housed in Individually Ventilated Cages. – Scand. J. Laboratory Animal Science, 2019, Vol. 45, Number 3. – 9 p.
  5. Messer J.G, La S., Kipp D.E., Castillo E.J., Yarrow J Comp Med. 2019 Oct; 69(5): 384–400..F., Jorgensen M., Wnek R.D., Kimmel D.B., Aguirre J.I. Diet-induced Generalized Periodontitis in Lewis Rats. Comp. Med. 2019 Oct; 69(5): 384–400. DOI: 10.30802/AALAS-CM-18-000113.

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