Knowledge the characteristics of the morphological structure, the main structural and functional components of human skin and laboratory animals is the foundation of rational planning of pharmacological and toxicological preclinical studies of skin dosage forms in aspect. The choice of laboratory animals must be justified for accurate translation of the results of pre-clinical studies into clinical studies (early phase). A brief report shows the comparative morphology of human skin and certain types of laboratory animals: mouse, rat, guinea pig, hamster, rabbit, ferret, minipig. Structural similarities and differences of skin layers (epidermis, dermis, gmpoderm) are described. A comparative characteristic of the thickness of the epidermis and dermis in different species, carried out on the analysis of literature data and results obtained in their own research. A comparative analysis was conducted both between humans and laboratory animals, and between species.
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