Любашина О.А.

The pancreas is an unpaired parenchymal organ that belongs to the glands of mixed secretion. It includes the exocrine and endocrine parts, while participating in digestion, and in the regulation of carbohydrate, protein and fat metabolism in tissues.

This model is used to evaluate the inhibitory activity of drugs aimed at vascular permeability normalization. The barrier function of endothelium is disrupted on some pathologies.

The article discusses the importance of integration of pharmacokinetics in toxicity testing. This will be helpful in interpretation of the results of toxicological studies and ensure the development of a rational study design.