Khrushchova A. M.

In the domestic and foreign literature, there are a number of differences on the criteria for including laboratory guinea pigs in preclinical studies.

Sepsis is a life-threatening pathological condition of the body that occurs as a result of a systemic inflammatory response to infection. The development of sepsis can occur as a result of various bacterial, fungal and viral infections, such as COVID-19 or the flu.

Assessing organs mass in toxicology studies is an integral part of the study of pharmaceuticals, chemicals, and medical devices.

Study of the respiratory function in laboratory animals is a frequent task in the study of drug toxicity, to assess pharmacological safety, the study of pharmacodynamics.

Today, scientists around the world are paying more and more attention to the principles of 3 “Rs” when working with laboratory animals.

Rabbits are often chosen as animal models for the study of eye pathologies, including pathologies of the retina and choroid. Fixation of the eyeball of a rabbit is a difficult task. In the process of fixation, many artifacts occur in it.