Diet-Induced Models Of Metabolic Disorders. Experimental Metabolic Syndrome

Makarova M.N., Makarov V.G. HOUM OF PHARMACY Research-and-Production Association; 3, Zavodskaya St., Build. 245, Kuzmolovsky Urban-Type Settlement, Vsevolozhsky District, Leningrad Region 188663 e-mail: makarova.mn@doclinika.ru

Abstract

A significant increase in the prevalence of metabolic syndrome (MS) over the past 2 decades contributing to the growth of mortality due to coronary heart disease, stroke, cancer and other diseases. The specified necessitates the creation of adequate experimental models to search for means of prevention and treatment of MS. The closest the etiology and pathogenesis of MS are diet-induced models that use high-calorie diets with increased fat content (up to 60% of the total caloric content of the diet), sucrose and fructose (60-70% of total calories) and combined diets (43% fat and 15-17% sucrose or fructose, and others). To accelerate the development of manifestations of MS high-calorie diets combined with the introduction of small doses of streptozotocin. Of the MS model in rodents, the most commonly used at present, do not give an accurate picture of human pathology, so along with them, we need to use the MS model on rabbits, mini-pigs and other animals more closely at the anatomy and physiology of man. To assess the development of MS using the parameters of lipid, protein and carbohydrate metabolism, anthropometric and many other parameters.

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