The effect of physic-chemical properties of the components of dosage forms on the selection of vehicle for the administration to laboratory animals

D.V. Kirichenko

Research and manufacturing company «Home оf Pharmacy»,

188663, Russia, Leningradskiy region, Vsevolozhskiy district, Kuzmolovskiy t.s., Zavodskaya st. 3–245

Е-mail:  kirichenko.dv@doclinika.ru

Abstract

This paper provides the results of the research focused on selection of the carrier of solid dosage forms, which contain components able to form polymer chains. Up to 90% of all dosage forms used as objects for research are solid dosage forms, such as tablets, capsules etc. These are the most popular and common dosage forms. On the other hand, what is comfortable if used by a man can not always be handy in preclinical tests carried out on small laboratory animals. In this paper we list the requirements for carriers, briefly review the excipients which belong to polymers, and suggest an option as how to work with such dosage forms.

Based on several medications it is determined that the chemical nature of polymers affects primarily the colloidal properties of suspension which form in contact with water. It is determined that in water the majority of polymers, which are a part of solid dosage forms, form suspension solid to aggregation, which do not need additional stabilization with the help of dispersion phase. It is important to take into account not only the presence of polymers in a specific dosage form, but also the properties of these polymers.

Thus, the selection of the carrier of dosage forms, which have polymers as a part either of their active ingredients or of their excipients, requires an integrated approach which should take into consideration the affection of the carrier, used for dosing laboratory animals, on physico-chemical and adsorbing properties of the active ingredients. 

Full text avaliable in Russain only

Acknowledgements. The study was performed without external funding.

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