Шабунин Б.В.

Determination of pharmacokinetic parameters in pharmacokinetic (PK) and toxicokinetic (TK) studies is a mandatory component of medicinal products preclinical study.

Laboratory rodent nurseries have a sufficient assortment of rodents, but when non-rodents are required, the choice is quite limited. The purpose of our research was to create methodological recommendations for conducting entrance control.

A significant decrease in blood glucose levels leads to the development of delayed cognitive impairment, caused by hypoglycemia damage of brain neurons.

Many animal species, including dogs, are involved in preclinical studies.

Despite numerous attempts to find alternative models to evaluate the efficacy and safety of drugs, it is currently impossible to completely abandon research on large laboratory animals.