Peripheral sensory hypersensitization development after global cerebral ischemia in rats

V. Kashkin1, 2, ORCID 0000-0002-7202-0233,

S. Arutyunyan1

1Valdman Institute of Pharmacology, First Pavlov State Medical University, St.-Petersburg, 197022, Russia

2Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, 194223, Russia

Е-mail: kashkinv@gmail.com

Abstract

It is known that in the post-stroke period is characterized by the cognitive deficit and the development of chronic pain syndrome caused by reduction of sensory thresholds of the primary afferents and hypersensitization of nerve fibers. In the present work, we studied the possibility of hypersensitization evaluation by tactile sensitivity measuring in rats after global cerebral ischemia caused by bilateral occlusion of the common carotid arteries. It has been shown that global cerebral ischemia resulted in increased sensitivity to plantar tactile stimulation, which indicates the development of tactile allodynia defined as pain due to a stimulus that does not normally provoke pain. Memantine, which has cognitive-enhancing potential and reduces neuronal damage in global and focal animal models of brain ischemia, has been used as a positive control drug. Memantine treatment resulted in tactile reactivity normalization. Thus, the assessment of tactile allodynia in modeling experimental cerebral ischemia in rats can be used as an additional quantitative marker to estimate the pharmacological activity of drug candidates intended for the treatment of cerebrovascular disorders.

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