Peripheral sensory hypersensitization development after global cerebral ischemia in rats

DOI: 10.29296/2618723X-2019-04-11

V. Kashkin1, 2, ORCID 0000-0002-7202-0233,

S. Arutyunyan1

1Valdman Institute of Pharmacology, First Pavlov State Medical University, St.-Petersburg, 197022, Russia

2Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, 194223, Russia

Е-mail: [email protected]


Keywords: tactile allodynia global cerebral ischemia experimental model

For citation:

Kashkin V.A., Arutyunyan S.S. Peripheral sensory hypersensitization development after global cerebral ischemia in rats . Laboratory Animals for Science. 2019; 4. https://doi.org/10.29296/2618723X-2019-04-11

Abstract

It is known that in the post-stroke period is characterized by the cognitive deficit and the development of chronic pain syndrome caused by reduction of sensory thresholds of the primary afferents and hypersensitization of nerve fibers. In the present work, we studied the possibility of hypersensitization evaluation by tactile sensitivity measuring in rats after global cerebral ischemia caused by bilateral occlusion of the common carotid arteries. It has been shown that global cerebral ischemia resulted in increased sensitivity to plantar tactile stimulation, which indicates the development of tactile allodynia defined as pain due to a stimulus that does not normally provoke pain. Memantine, which has cognitive-enhancing potential and reduces neuronal damage in global and focal animal models of brain ischemia, has been used as a positive control drug. Memantine treatment resulted in tactile reactivity normalization. Thus, the assessment of tactile allodynia in modeling experimental cerebral ischemia in rats can be used as an additional quantitative marker to estimate the pharmacological activity of drug candidates intended for the treatment of cerebrovascular disorders.

Full text avaliable in Russain only

References

  1. Aski M.L., Rezvani M.E., Khaksari M., Hafizi Z., Pirmoradi Z., Niknazar S., Mehrjerdi F. Z. Neuroprotective effect of berberine chloride on cognitive impairment and hippocampal damage in experimental model of vascular dementia. Iran J Basic Med Sci. 2018. Vol. 21; 1: 53–8. http://dx.doi.org/10.22038/ijbms.2017.23195.5865
  2. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci Methods. 1984. Vol. 11; 1: 47–60.
  3. Шекунова Е., Кашкин В., Макарова М., Макаров В. Экспериментальные модели когнитивных нарушений. Международный вестник ветеринарии. 2016; 1: 105–18. [Shekunova E., Kashkin V., Makarova M., Makarov V. Modeling of cognitive impairment. Mezhdunarodnyi vestnik veterinarii. 2016; 1: 105–18] (in Russ.)
  4. Moser V.C., McDaniel K.L., Phillips P.M. Rat strain and stock comparisons using a functional observational battery: baseline values and effects of amitraz. Toxicol Appl Pharmacol. 1991. Vol. 108; 2: 267–83.
  5. Mathiasen J., Moser V. The Irwin Test/Functional Observational Battery (FOB) for Assessing the Effects of Compounds on Behavior, Physiology, and Safety Pharmacology in Rodents. Current Protocols in Pharmacology. 2018; Vol. 83; 1: 42. http://dx.doi.org/10.1002/cpph.43
  6. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994. Vol. 53; 1: 55–63. http://dx.doi.org/10.1016/0165-0270(94)90144-9
  7. Dixon W.J. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol. 1980. Vol. 20: 441–62. https://doi.org/10.1146/annurev.pa.20.040180.002301
  8. Xu L., Lin C.R., Liu J.X., Ren J. X., Li J.M., Wang M., Li H.H., Song W. T., Yao M.J., Wang G.R. [Effect of sailuotong capsule on intervening cognitive dysfunction of multi-infarct dementia in rats]. Zhongguo Zhong Yao Za Zhi. 2012. Vol. 37; 19: 2943–6.
  9. Li T., Luo Z., Liu Y., Wang M., YuX., Cao C., Liao Z., Ding Y., Yue S. Excessive Activation of NMDA Receptors Induced Neurodevelopmental Brain Damage and Cognitive Deficits in Rats Exposed to Intrauterine Hypoxia. Neurochem Res. 2018. Vol. 43; 3: 566–80. 10.1007/s11064-017-2451-1
  10. Oh H., Seo W. A Comprehensive Review of Central Post-Stroke Pain. Pain Management Nursing. 2015. Vol. 16: 5: 804–18. https://doi.org/10.1016/j.pmn.2015.03.002
  11. Klit H., Finnerup N. B., Jensen T. S. Central post-stroke pain: clinical characteristics, pathophysiology, and management/ The Lancet Neurology. 2009. Vol. 8; 9: 857–68. https://doi.org/10.1016/S1474-4422(09)70176-0
  12. Takami K., Fujita-Hamabe W., Harada S., Tokuyama S. Aβ and Aδ but not C-fibres are involved in stroke related pain and allodynia: an experimental study in mice. Journal of Pharmacy and Pharmacology. 2011. Vol. 63; 3: 452–6. http://dx.doi.org/10.1111/j.2042-7158.2010.01231.x
  13. Hyakkoku K., Umeda N., Shimada S., Imai T., Morioka Y., Sakaguchi G., Hara H. Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats. Brain Research. 2019. Vol. 1715: 35–40. https://doi.org/10.1016/j.brainres.2019.03.019
  14. Wang Y.-C., Sanchez-Mendoza E. H., Doeppner T. R., Hermann D. M. Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity. Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism. 2017. Vol. 37; 3: 980–93. http://dx.doi.org/10.1177/0271678X16648971
  15. Lai T. W., Shyu W. C., Wang Y. T. Stroke intervention pathways: NMDA receptors and beyond/ Trends Mol Med. 2011. Vol. 17; 5: 266–75. http://dx.doi.org/10.1016/j.molmed.2010.12.008
  16. Lai T. W., Zhang S., Wang Y. T. Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol. 2014. Vol. 115: 157–88. http://dx.doi.org/10.1016/j.pneurobio.2013.11.006
  17. Park J. W., Suh G. I., Shin H. E., Park G. E. Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection. Cephalalgia. 2012. Vol. 32; 4: 308–16. http://dx.doi.org/10.1177/0333102411435986
  18. Chen S.-R., Samoriski G., Pan H.-L. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology. 2009. Vol. 57; 2: 121–6. http://dx.doi.org/10.1016/j.neuropharm.2009.04.010

You may be interested