It is known that in the post-stroke period is characterized by the cognitive deficit and the development of chronic pain syndrome caused by reduction of sensory thresholds of the primary afferents and hypersensitization of nerve fibers.
The aim of this study was to test a model of the formation of degenerative changes in the intervertebral discs in rabbits, as a possible model of discopathy, and to develop a simple and reproducible protocol.
To date, there are two ways to register a reproduced drug (generic) on the pharmaceutical market in terms of preclinical studies: presenting reviews of preclinical and clinical studies of the original drug or reports on the conducted preclinical studies (acute and subacute toxicity of the generic
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