Animal in vivo modeling of administration of medicinal products for intestinal delivery

Alexandrovskaya N.V.,
Tokareva L.A.,
Kruglova A.A.

Researcher of the Department Preclinical study, Federal State Unitary Enterprise "Scientific Center "Signal",

Russia, 115487, Moscow, st. Nagatinskaya, Build. 16A, Corp. 5

Е-mail: natali-aleks@mail.ru

Abstract

When creating new, modern forms of drugs, when developing carriers of drug compounds, or when developing systems for targeted drug delivery for any type of administration, the understanding of the processes occurring in various environments of a biological organism remains an urgent problem. It is important to study the effect of the physicochemical properties of the media surrounding the new drug on the safety of the properties of the developed delivery system, on its ability to deliver the drug to a given goal, on the ability to protect the drug from degradation, which ultimately affects the biological activity of the delivered compound and treatment effectiveness. When developing new drugs to ensure targeted enteral release, it is important to monitor the targeted delivery of pharmaceutical substances to specific sections of the gastrointestinal tract and establish the fact of successful delivery of the drug to the target. To solve the problem of targeted enteral delivery of biologically active substances, various types of protective shells of the pharmacological substance, systems for controlling the dissolution and disintegration of the dosage form, and new systems that help to overcome the body’s natural barriers to the target organ have been created and continue to be created. The set of methods to access the effectiveness of target delivery is the independent part of nonclinical studies of such preparations. However, the existing methods of biodegradability and sustainability do not give a complete and reliable answer about what processes and what changes occur with the new drug.

The aim of current study – the development of novel method for animal in vivo modeling of administration of medicinal products for intestinal delivery through transabdominal surgical insertion into the intestine of laboratory animals.

A method of surgical transabdominal administration of drugs was developed and tested to study their stability and effectiveness with high survival rate in experimental animals.

Thus, the analysis of the results showed that the proposed methodological approach reproduces the aspects of the enteral use of new dosage forms, and is acceptable for evaluating their pharmacological effectiveness of the data.

 Full text avaliable in Russain only

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